Granulocyte colony-stimulating factor and reproductive medicine: A review

Granulocyte colony-stimulating factor and reproductive medicine: A review

Blog Article

Background: Recently, the use of granulocyte colony-stimulating factor (G-CSF) has been proposed to improve pregnancy outcomes sara stedy stand aid in reproductive medicine.Objective: A systematic review of the current use of G-CSF in patients who have difficulty conceiving and maintaining pregnancy was performed.Materials and Methods: Two electronic databases (PubMed/ Medline and Scopus) were searched.Study selection, data extraction and quality assessment were performed in duplicate.The subject codes used were granulocyte colony-stimulating factor, G-CSF, recurrent miscarriage, IVF failure, and endometrium.

Results: The search of electronic databases resulted in 215 citations (PubMed/ Medline: 139 and Scopus: 76), of which 38 were present in both databases.Of the remaining 177 publications, seven studies were included in the present review.Conclusion: Treatment with G-CSF is a novel proposal for immune therapy in patients with recurrent miscarriage and implantation failure following cycles of IVF.However, a larger number poise pads in bulk of well-designed studies are required for this treatment to be established.